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US 2025/0367259 A1Published application
Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
AssigneeThe Scripps Research Institute
InventorsWeijun SHEN, Pengyu YANG, Huafei ZOU, Peter G. SCHULTZ
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Abstract
Methods and compositions are provided for extending the half-life of a therapeutic agent A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
Claims17
1-7. (canceled)
A peptide comprising an amino acid sequence of any one of SEQ ID NO:
- 30-32, 35-41, or 52-53.
A peptide comprising an amino acid sequence of any one of SEQ ID NO:
- 42-51.
Dependencies are inferred from the claim text.