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US 2025/0367256 A9Published application
Methods for promoting wound healing and hair growth comprising gdnf administration
AssigneeThe Jackson Laboratory
InventorsRobert E. Braun, Manju Sharma
Life of this patent
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Abstract
The present invention generally relates to uses of glial cell line-derived growth factor (GDNF) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of GDNF, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein. The invention relates also to formulations and kits for achieving the indicated pharmaceutical advantages.
Claims21
1-23. (canceled)
A method for promoting cutaneous wound healing, the method comprising:
- administering to a cutaneous wound of a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount promotes healing of the cutaneous wound.
A method for promoting vascularization of a wound, the method comprising:
- administering to a wound of a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount promotes vascularization of the wound, and wherein the wound is selected from a chronic wound, a burn wound, and a freezing injury.
Dependencies are inferred from the claim text.