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AssigneesInstitute of Zoology, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine
InventorsWei LI, Qi ZHOU, Zheng-Quan HE, Zongbao LU, Shuai WANG, Xin WANG, Xuewei YUAN, Liu WANG
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Provided is use of a substance capable of up-regulating ISG gene expression in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The substance for up-regulating ISG gene expression is selected from one or two or more of an MAPK inhibitor, a retinoic acid receptor-related orphan receptor inhibitor, a protein synthesis inhibitor, and an interferon (IFNγ, β, λ) or alarmin (S100A8/A9) protein. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.
1-21. (canceled)
Use of a substance capable of up-regulating ISG gene expression in the promotion of regeneration and repair capacity of a tissue, complex structure or organ of a mammal or in the treatment of a disease related to regeneration and repair of a tissue, complex structure or organ of a mammal.
A composition, wherein it comprises a protein synthesis inhibitor, and an all-trans retinoic acid and a BMP activator, preferably the protein synthesis inhibitor is cycloheximide (CHX), and the BMP activator is BMP signaling agonist sb4.
A method for promoting regeneration and repair of a tissue, complex structure or organ of a mammal, comprising administering a substance capable of up-regulating ISG gene expression or a composition comprising the substance capable of up-regulating the ISG gene expression to a subject in need thereof.
Dependencies are inferred from the claim text.