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US 2025/0361284 A1Published application
Transposase fusion proteins for use in cell and gene therapy
OwnerMichael HUDECEK, Narayanavari A. SUNEELinventors
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Abstract
Fusion proteins and methods for conditionally fine-tuning transposase protein stability and activity for clinical applications are provided herein
Claims43
A complex, comprising:
- A) a destabilizing domain or degron tag;
- and
- B) a second protein domain or protein having enzymatic activity,
- wherein the destabilizing domain or degron tag is capable of modulating the half-life of the complex and/or is capable of modulating the enzymatic activity of the complex, and
- wherein the complex is capable of binding to a signaling molecule or ligand.
2 more elements
Dependencies are inferred from the claim text.