1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease

A method of treating a medical condition characterized by overexpression of a kinase, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I) below:

• or a tautomer thereof, or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is aryl or heteroaryl, each of which is optionally substituted;
• R2 is H, halo, OH, CN, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 thioalkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, aryl, or heteroaryl;
• and
• A is aryl or 5- or 6-membered heteroaryl;
• wherein each of the C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 thioalkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, aryl, and heteroaryl is optionally substituted with one or more moieties selected from the group consisting of halo, OH, CN, CF3, NH2, NO2, C1-6 alkyl, C1-6 haloalkyl, C1-6 thioalkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, C2-8 heterocycloalkenyl, C2-6 alkenyl, C2-6 alkynyl, C1 6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C2-6 dialkylamino, C7-12 aralkyl, C1-12 heteroaralkyl, aryl, heteroaryl, —C(O)R, —C(O)OR, —C(O)NRR′, —C(O)NRS(O)2R′-C(O)NRS(O)2NR′R″, —OR, —OC(O)NRR′, —NRR′, —NRC(O)R′, —NRC(O)NR′R″, —NRS(O)2R′, —NRS(O)2NR′R″, —S(O)2R, and —S(O)2NRR′,
• in which each of R, R′, and R″, independently, is H, halo, OH, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, C2-8 heterocycloalkyl, aryl, or heteroaryl, or R and R′, or R′ and R″, together with the nitrogen to which they are attached, form C2-8 heterocycloalkyl.