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US 2025/0360331 A1Published application
Methods and systems for modulating cellular activation
AssigneeThe University of Chicago
InventorsBozhi Tian, Menahem Rotenberg, Aleksander Prominski
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Abstract
This disclosure relates to methods for modulating activity of cells and tissue with materials that are capable of being activated by light, such methods useful for treating diseases. The disclosure also provides devices and systems suitable for use in such methods, particularly devices and systems having oxygen plasma-treated p-type (boron) silicon.
Claims20
A system for treating a disease in a subject by modulating activation of a cell, the system comprising:
- one or more oxygen (O2) plasma-treated p-type silicon devices;
- a light emitter configured to emit light at a stimulation wavelength, wherein the one or more O2 plasma-treated p-type silicon devices provide, to the cell they are in contact with, an excitatory stimulus in response to receiving light at the stimulation wavelength;
- and
- a controller that is operably coupled to the light emitter, wherein the controller comprises one or more processors, wherein the controller is programmed to perform controller operations including:
- operating the light emitter to provide the light to the cell.
2 more elements
A method for optically training the myocardium in a subject to beat at a target frequency, the method comprising:
- contacting the myocardium with one or more oxygen (O2) plasma-treated p-type silicon devices;
- and
- operating a light emitter to provide, during a training period of time, a plurality of pulses of light at a stimulation wavelength to the myocardium, wherein the plurality of pulses of light are provided at the target frequency.
Dependencies are inferred from the claim text.