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US 2025/0360205 A1Published application
Nod1 modulators and uses thereof
AssigneeAcademia Sinica
InventorsWei-Chieh CHENG, Hung-Chang TSAI
Life of this patent
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Abstract
Disclosed herein are compounds having adjuvant properties, vaccines including the adjuvant compounds, and their uses in the prophylaxis or therapy for respiratory virus infection.
Claims28
A compound of formula (I), a pharmaceutically acceptable salt, solvate or stereoisomer thereof,
- wherein,
- X1 and X2 are independently nil, —NH or —(C═O);
- R1 and R3 are independently hydroxyl or alkoxy;
- R2 is —COOH or —CH2OH;
- R4 is hydrogen or C1-6 alkyl;
- R5 is hydrogen or C1-20 alkyl optionally substituted with a substituent selected from the group consisting of cycloalkyl, phenyl, biphenyl and —O-phenyl;
- and
- the phenyl, the biphenyl or the —O-phenyl is optionally substituted with one or more halo, alkyl, or alkoxy.
5 more elements
28-30. (canceled)
Dependencies are inferred from the claim text.