Sars-cov-2 variants of concern-specific multi-antigens universal vaccine
AssigneeThe Regents of the University of California
InventorLbachir BenMohamed
Life of this patent
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Abstract
Pan-coronavirus vaccines for inducing efficient, powerful and long-lasting protection against all Coronaviruses infections and diseases, comprising multiple highly conserved large sequences which may comprise one or more conserved B, CD4 and CDS T cell epitopes that help provide multiple targets for the body to develop an immune response for preventing a Coronavirus infection and/or disease. In certain embodiments, the large sequences are conserved proteins or large sequences, e.g., sequences that are highly conserved among human coronaviruses and/or animal coronaviruses (e.g., coronaviruses isolated from animals susceptible to coronavirus infections).
Claims29
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A pre-emptive pan-coronavirus vaccine composition, the composition comprising, or comprising a sequence encoding:
- at least two conserved coronavirus antigens selected from:
- (i) a conserved coronavirus Spike protein;
- (ii) a conserved coronavirus NSP2 protein;
- (iii) a conserved coronavirus NSP3 protein;
- (iv) a conserved coronavirus NSP14 protein;
- and (v) a conserved coronavirus Nucleoprotein.
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A pre-emptive pan-coronavirus vaccine composition, the composition comprising, or comprising a sequence encoding one or more large sequence coronavirus proteins, wherein the one or more large sequence coronavirus proteins comprise:
- a conserved coronavirus Spike protein;
- a conserved coronavirus NSP2 protein;
- a conserved coronavirus NSP14 protein;
- and a conserved coronavirus Nucleoprotein.
Dependencies are inferred from the claim text.