Systems and methods for wireless neurosensing

A method for sensing signals, the method comprising:

• implanting an implant into a skull of a subject;
• generating, with an interrogator that is external to the subject, a carrier signal;
• transmitting the carrier signal from the interrogator to the implant;
• receiving, by the implant, the carrier signal from the interrogator;
• mixing, by the implant, the carrier signal with signals of interest (SoI) from the subject to generate a modulated signal;
• backscattering, by the implant, the modulated signal to the interrogator;
• and
• receiving, by the interrogator, the modulated signal from the implant
• the implant comprising:
• at least two electrodes;
• and
• a sensor connected to the at least two electrodes and comprising a transistor, a diode, and a first antenna configured to communicate with the interrogator while the implant is embedded in the subject,
• the interrogator comprising a second antenna configured to communicate with the first antenna while the implant is embedded in the subject and the interrogator is external to the subject,
• the implant and the interrogator not being connected to each other by any wire,
• the subject being a mammalian subject or an organoid, and
• the SoI comprising at least one of neural signals, cardiac signals, and electrochemically-based signals.

A system for sensing signals, the system comprising:

• an implant configured to be embedded in a subject;
• and
• an interrogator configured to communicate with the implant while being external to the subject,
• the implant comprising:
• at least two electrodes;
• and
• a sensor connected to the at least two electrodes and comprising a transistor, a diode, and a first antenna configured to communicate with the interrogator while the implant is embedded in the subject,
• the interrogator comprising a second antenna configured to communicate with the first antenna while the implant is embedded in the subject and the interrogator is external to the subject,
• the interrogator being configured to generate a carrier signal, transmit the carrier signal to the implant, and receive a modulated signal from the implant,
• the implant being configured to receive the carrier signal from the interrogator, mix the carrier signal with signals of interest (SoI) from the subject to generate the modulated signal, and backscatter the modulated signal to the interrogator,
• the implant and the interrogator not being connected to each other by any wire,
• the system further comprising a demodulation circuit connected to the interrogator and configured to demodulate the modulated signal,
• the transistor being a bipolar junction transistor (BJT),
• the diode being a Schottky diode,
• the implant being coated with a biocompatible material,
• the first antenna and the second antenna each being a near-field communication (NFC) antenna,
• the first antenna comprising a shorting pin,
• the implant further comprising a passive impedance matching (PIM) network,
• the subject being a mammalian subject or an organoid, and
• the SoI comprising at least one of neural signals, cardiac signals, and electrochemically-based signals.