Medical imaging systems and methods

A method comprising:

• receiving a first signal representative of light collected by a first pixel included in a two-by-two array of pixels, the first signal comprising data representative of a combination of a first color component of visible light and fluorescence illumination,
• receiving a second signal representative of light collected by a second pixel included in the two-by-two array of pixels, the second signal representative of a second color component of the visible light,
• receiving a third signal representative of light collected by a third pixel included in the two-by-two array of pixels, the third signal representative of a combination of the second color component and the fluorescence illumination,
• receiving a fourth signal representative of light collected by a fourth pixel included in the two-by-two array of pixels, the fourth signal representative of a combination of a third color component of the visible light and the fluorescence illumination,
• identifying, based on the second signal and the third signal, a fluorescence illumination component of the third signal that is representative of the fluorescence illumination,
• generating, based on the fluorescence illumination component and the first signal, a processed first signal representative of only the first color component, and
• generating, based on the fluorescence illumination component and the fourth signal, a processed fourth signal representative of only the third color component.

A non-transitory computer-readable medium storing instructions that, when executed, direct a processor of a computing device to perform a process comprising:

• receiving a first signal representative of light collected by a first pixel included in a two-by-two array of pixels, the first signal comprising data representative of a combination of a first color component of visible light and fluorescence illumination,
• receiving a second signal representative of light collected by a second pixel included in the two-by-two array of pixels, the second signal representative of a second color component of the visible light,
• receiving a third signal representative of light collected by a third pixel included in the two-by-two array of pixels, the third signal representative of a combination of the second color component and the fluorescence illumination,
• receiving a fourth signal representative of light collected by a fourth pixel included in the two-by-two array of pixels, the fourth signal representative of a combination of a third color component of the visible light and the fluorescence illumination,
• identifying, based on the second signal and the third signal, a fluorescence illumination component of the third signal that is representative of the fluorescence illumination,
• generating, based on the fluorescence illumination component and the first signal, a processed first signal representative of only the first color component, and
• generating, based on the fluorescence illumination component and the fourth signal, a processed fourth signal representative of only the third color component.