Emulator of subcutaneous absorption and release

A modular in vitro device configured as a subcutaneous absorption model, comprising:

• a center chamber formed by a center chamber body having a first side with at least one first opening and a second side with at least one second opening;
• a matrix material configured to be included in the center chamber during measurement of absorption of a test agent;
• a first side chamber formed by a first side chamber body having a first open side that is configured to couple with the first side of the center chamber, the first open side having at least one first side opening configured to fluidly couple with the center chamber through the at least one first opening when the first side chamber is mounted to the center chamber;
• at least one first membrane configured to be positioned between the first side of the center chamber and first open side of the first side chamber to cover the at least one first opening and at least one first side opening, wherein each first membrane includes a first size exclusion cutoff;
• a second side chamber formed by a second side chamber body having a second open side that is configured to couple with the second side of the center chamber, the second open side having at least one second side opening configured to fluidly couple with the center chamber through the at least one second opening when the second side chamber is mounted to the center chamber;
• and
• at least one second membrane configured to be positioned between the second side of the center chamber and second open side of the second side chamber to cover the at least one second opening and at least one second side opening, wherein the second membrane includes a second size exclusion cutoff,
• wherein the center chamber, first side chamber, and second side chamber are configured to be modular for combining with the first membrane and second membrane in a lateral arrangement.