Matrix and associated sample or mixing cup used for removing components of a liquid sample

In combination:

• a mixing cup, the mixing cup defining an interior cavity for receiving a liquid sample;
• and
• an insert mounted within the interior cavity of the mixing cup, the mixing cup and the insert being used by an automated chemical analyzer for removing a targeted component of the liquid sample received by the mixing cup, the automated chemical analyzer including a sample metering device having a pipette fitted with a disposable pipette tip for aspirating the liquid sample into the pipette tip and expelling the liquid sample therefrom;
• wherein the insert includes a porous matrix formed of or carrying in an immobilized state functionalized particles having properties such that the targeted component of the liquid sample adheres to the functionalized particles, the porous matrix having a predetermined porosity that allows the liquid sample to flow therethrough;
• wherein, when the liquid sample is expelled from the pipette tip, the liquid sample is drawn into the matrix of the insert by capillary action or forced into the matrix by positive hydraulic or pneumatic pressure exerted thereon by the pump of the sample metering device, whereupon the targeted component of the liquid sample adheres to the immobilized functionalized particles of the matrix;
• and
• wherein, under negative hydraulic or pneumatic pressure exerted on the liquid sample within the matrix by the pump of the sample metering device, liquid sample free of the targeted component or having a reduced concentration thereof is drawn from the matrix of the insert and aspirated into the pipette tip for subsequent testing by the automated chemical analyzer.