Virus-specific recombinant t cell receptors and t cells comprising them
AssigneesSheba Impact Ltd., Bar-Ilan University, Ministry of Health
InventorsGal CAFRI, Nira VARDA-BLOOM, Elad JACOBY, Amihai LIEBERMAN, Neta ZUCKERMAN, Ayal HENDEL, Nimrod BEN HAIM
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Abstract
Provided herein are compositions comprising T cells expressing a recombinant virus-specific T cell receptor (rTCR-V) specific for a viral antigen restricted by a predetermined HLA type, rTCR-Vs, methods for preparing them, their use for treatment, and libraries containing such rTCR-V or T cells comprising them.
Claims17
1-51. (canceled)
A recombinant virus-specific T cell receptor (rTCR-V) specific to a cytomegalovirus (CMV) or an adenovirus (ADV) viral antigen restricted by a predetermined HLA type, the rTCR-V comprising six CDRs having sequences selected from the group consisting of:
- a. SEQ ID NOs 33, 34, 5, 35, 36, and 6;
- b. SEQ ID NOs 29, 30, 3, 31, 32, and 4;
- and
- c. SEQ ID NOs 25, 26, 1, 27, 28, and 2.
Dependencies are inferred from the claim text.