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US 2025/0353838 A1Published application
Method for preparing 4'-thio-5-aza-2'-deoxycytidine
AssigneesPinotbio, Inc., St Pharm Co., Ltd.
InventorsDoo Young JUNG, Jin Soo LEE, Hyun Yong CHO, Ah Reum KIM, Mun Sik SEO, Jun Young CHOI
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Abstract
The present invention relates to a method for preparing 4′-thio-5-aza-2′-deoxycytidine which exhibits DNMT1 inhibitory activity. The production method according to the present invention can enhance reaction efficiency through efficient process development and can stereoselectively prepare 4′-thio-5-aza-2′-deoxycytidine, and thus is economical and appropriate for mass production.
Claims16
A method for preparing 4′-thio-5-aza-2′-deoxycytidine, the method comprising:
- (S-1) preparing a compound represented by the following Chemical Formula 2 from a compound represented by the following Chemical Formula 1;
- (S-2) preparing a compound represented by the following Chemical Formula 3 from the compound represented by Chemical Formula 2;
- and
- (S-3) preparing a compound represented by the following Chemical Formula I from the compound represented by Chemical Formula 3:
- wherein R is a protecting group of diol including one or more Si atom, and
- X is halo.
3 more elements
Dependencies are inferred from the claim text.