US 2025/0353834 A1 · PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS

Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

AssigneeVertex Pharmaceuticals Incorporated

InventorsCristian HARRISON, Christopher John DAVIS, Simon Robert Everitt, Enrico EMER, Michael Edward O'Donnell, Stephen SHANAHAN, Mireia Sidera PORTELA, Bruno Artur SOUSA, Shujauddin M. CHANGI, Berenice L. LEWANDOWSKI, Maninder PANESAR, Andrew MCTIERNAN, Tharanga K. WIJETHUNGA

Life of this patent

Estimating the term…

Abstract

Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.

Claims33

Dependent claims

A method of preparing a compound of formula I, or a salt thereof:

comprising converting a compound of formula III, or a salt thereof:
to the compound of formula I,
optionally wherein said converting the compound of formula III to the compound of formula I comprises preparing a compound of formula IV:

Dependencies are inferred from the claim text.