Cannabicyclol derivatives and preparation methods thereof
AssigneesKunming University of Science and Technology, West China Hospital, Sichuan University
InventorsRongtao LI, Xudong ZHAO, Hejiang LUO, Tao JIANG, Nan LIU, Ye YU
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Abstract
The present disclosure provides cannabicyclol derivatives and preparation methods thereof, belonging to the field of biomedical technology. In the present disclosure, citral (3,7-Dimethyl-2,6-octadienal) and derivatives thereof, and olive alcohol (1,3-Dihydroxy-5-pentylbenzene) and derivatives thereof are used as raw materials for the efficient synthesis of the cannabicyclol derivatives in a one-pot manner under an action of ethylenediamine and a photocatalyst.
Claims20
A cannabicyclol derivative, comprising a structural formula as follows:
- wherein
- R1 is selected from hydrogen, substituted or unsubstituted linear alkyl, substituted or unsubstituted branched alkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl,
- R2 and R3 are independently selected hydrogen, substituted or unsubstituted linear alkyl, substituted or unsubstituted branched alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted ester, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl,
- R4 is selected from hydrogen, substituted or unsubstituted linear alkyl, substituted or unsubstituted branched alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and
- R5 is selected from hydrogen, hydroxy, substituted or unsubstituted linear alkyl, substituted or unsubstituted branched alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
Dependencies are inferred from the claim text.