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US 2025/0353819 A1Published application
Aryl hydantoin compounds and methods of use
AssigneesBoard of Regents of the University of Nebraska, Monash University, Swiss Tropical and Public Health Institute
InventorsJonathan L. Vennerstrom, Derek A. Leas, Susan Charman, Jennifer Keiser
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Abstract
Provided herein are aryl hydantoin compounds having the structure of Formula (I) wherein X, R1, R2, R3, R4, and n are described herein. Also provided herein are compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I) in treating, inhibiting, and/or preventing a parasitic disease (e.g., Schistosomiasis).
Claims44
A compound, or pharmaceutically acceptable salt thereof, having the structure of Formula (I):
- wherein
- X is CH, CF, or N;
- each R1 is F;
- n is 0-3;
- R2 is selected from F, C, Br, CF2H, CF3, CFH2, CF2CH3, CFHCFH2, CH2CF3, and OCF3;
- each of R3 and R4 is independently selected from CH3, CD3, CFH2, CF2H, CF3, CF2CH3, CFHCFH2, CH2CF3, and OCF3;
- and
- when X is CF, R2 is CF3, and n is 0, R3 and R4 are not both CH3.
5 more elements
Dependencies are inferred from the claim text.