Computing system and method for optimizing proton therapy through real-time monitoring and synchronization of ionizing radiation acoustic and ultrasound imaging data

A computer-readable medium having stored thereon instructions that when executed cause a computer:

• to provide particle radiation to a region of interest of a subject and receive volumetric ionizing radiation acoustic imaging (iRAI) data and ultrasound imaging data from the region of in response the particle radiation;
• to determine from the iRAI data and the ultrasound imaging a position of the particle radiation in the region of interest, the position being a treatment position of the particle radiation;
• and
• to determine one or more parameters of the particle radiation for adjusting in response to the determination of the position.

A method for guiding radiation therapy, the method comprising:

• providing particle radiation to a region of interest of a subject and receive volumetric ionizing radiation acoustic imaging (iRAI) data and ultrasound imaging data from the region of in response the particle radiation;
• determining from the iRAI data and the ultrasound imaging, a position of the particle radiation in the region of interest, the position being a treatment position of the particle radiation;
• and
• determining one or more parameters of the particle radiation for adjusting in response to the determination of the position.