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US 2025/0352798 A1Published application
Treatment for loss of control disorders
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCasey HALPERN, Robert C. Malenka, Hemmings Wu
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Abstract
The present invention provides, inter alia, methods, apparatus, and systems useful for ameliorating impulse control disorders known to be extremely disabling and common to many neurological and psychiatric conditions using closed-loop (responsive) neuro stimulation.
Claims7
-26. (canceled)
A non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to perform operations comprising:
- receive brain wave activity in a frequency range of from 0-38 hertz that was recorded in the nucleus accumbens of a subject and in the absence of electrical stimulation administered to the brain;
- and
- detecting a change in power compared to a baseline in a delta band of the received brain wave activity corresponding to a frequency of from 1-4 Hz,
- wherein detection of an increase in power in the delta band indicates detection of the anticipatory biomarker in the form of a low frequency modulation, wherein said low frequency modulation precedes the onset of a disorder symptom manifestation,
- preventing the onset by causing the administration of, in response to detecting the anticipatory biomarker, an electrical stimulation to the nucleus accumbens of the subject.
2 more elements
Dependencies are inferred from the claim text.