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US 2025/0352694 A1Published application
Apparatus for degradation of an acoustically responsive biomaterial
AssigneeCarnegie Mellon University
InventorsRosalyn ABBOTT-BEAUREGARD, Megan DEBARI
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Abstract
A method and apparatus for degrading a hypodermal tissue scaffold involves exposing the scaffold to a low-intensity focused ultrasonic beam such as to burst gas vesicles trapped in the silk fibroin from which the scaffold is constructed. The rate of degradation can be controlled using ultrasonic beams of varying intensities. In one embodiment, the ultrasonic beams are administered trans-dermally to a hypodermal scaffold.
Claims19
An apparatus for degrading a silk fibroin tissue scaffold comprising:
- an ultrasonic transducer;
- a collimator, coupled to the output of the ultrasonic transducer;
- and
- a wave generator for driving the ultrasonic transducer;
- wherein focusing a beam of low-intensity ultrasound on a scaffold using the apparatus bursts gas vesicles in the silk fibroin causing degradation of the scaffold.
2 more elements
An apparatus for degrading a silk fibroin tissue scaffold comprising:
- an ultrasonic transducer;
- a collimator, coupled to the output of the ultrasonic transducer;
- and
- a wave generator for driving the ultrasonic transducer;
- wherein focusing a beam of low-intensity ultrasound on a scaffold using the apparatus causes microbubbles present in hydrophobic domains of the scaffold to implode, creating a shockwave that causes the degradation of the scaffold.
2 more elements
Dependencies are inferred from the claim text.