Synthetic cationic peptidomimetics, their derivatives and preparation thereof along with compositions for various medical applications

Cationic guanidine based peptides, oligomers, and oligomer-peptide hybrid compounds obtained from monomer, wherein monomer is represented by Formula 1 below:

• wherein X is
• A is selected from the group consisting of -L-,
• wherein the linker groups, “L, L1, L2,” is an aliphatic group independently selected from propyl (C3), butyl (C4), hexyl (C6), N-substituted alkyl amide, C1-C140 carbon atoms which are selected from group comprising an alkyl group, such as, methylene, ethylene, propylene, C4, C5, C6, C7, C8, C9 or C10;
• C1-C10, —C20, —C30, —C40, —C50-C60, —C70, —C80, —C90, —C100, —C110, —C120, —C130 or —C140, alkyl;
• cycloaliphatic, heterocyclic, aromatic, aryl, alkylaryl, arylalkyl, oxyalkylene radicals;
• a polyalkylene radical optionally interrupted by one or more, preferably one, oxygen, nitrogen or sulphur atoms, functional groups, saturated or unsaturated cyclic moiety;
• or polyethers selected from the group comprising PEG, derivatives of PEG, analogues of PEG;
• wherein linker groups “L, L1, L2”, comprise additional cationic moieties selected from the group comprising secondary or tertiary or quaternary amines, or guanidine, or aminoguanidine, diaminoguanidine or biguanidine or analogue, derivative cationic groups either in the backbone of the linker or side chain of the linker, the linker may additionally comprise an amide bond;
• wherein Pg1 or Pg2 is independently an orthogonal protecting group selected from the group consisting of Pg1 as Fmoc/Cbz or Boc/Cbz and Pg2 as Boc or Fmoc.