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US 2025/0352606 A1Published application
Pharmaceutical Composition for Promoting Neurogenesis and Method of Utilizing Gastrodia Elata Extract or Adenosine Analog for Promoting Neurogenesis
AssigneeAXR Pharma Inc.
InventorsYun-Lian Lin, Wei-Hsiang Hsu, Young-Ji Shiao
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Abstract
The present invention relates to a composition and a method of utilizing Gastrodia elata extract or an adenosine analog to promote neurogenesis, wherein the G. elata extract includes gastrodin, gastrodigenin, parishins, N6-(4-hydroxybenzyl) adenosine (T1-11) and 4-hydroxybenzaldehyde. The G. elata extract of the present invention exhibits anti-aging activity on nerve cells and can induce neurogenesis in mouse hippocampus.
Claims3
A pharmaceutical composition for inhibiting senescence of brain neurons of a subject, the composition comprising:
- Gastrodia elata extract prepared by the steps of:
- extracting pieces of Gastrodia elata tubers with a 70% aqueous ethanol solution at 50° C. overnight to obtain an extract solution;
- concentrating and drying the extract solution to obtain a crude extract;
- eluting the crude extract through a macro-porous resin column first with water, followed by 50% ethanol, to obtain the Gastrodia elata extract.
1 more element
Dependencies are inferred from the claim text.