Polyvalent bacteriophage compositions and methods for treatment of bacterial infections
AssigneeBaylor College of Medicine
InventorsAusten TERWILLIGER, Haroldo Hernandez SANTOS, Anthony MARESSO
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Abstract
Disclosed are compositions, devices, kits, and methods for prevention and/or treatment of Staphylococcus infection. In specific embodiments, Staphylococcus are S. pseudintermedius and/or S. aureus. Aspects of the present disclosure can be directed to bacteriophage compositions comprising one or more of vB_SpsM-DH2, vB_SpsS-DH5, and/or vB_SpsM-DS10. Further disclosed are devices and kits comprising such compositions, and methods for use of such compositions in treatment and prevention of pathogenic Staphylococcus infection.
Claims56
A composition comprising an isolated bacteriophage vB_SpsM-DH2 (Accession No. OM373548).
A composition comprising an isolated bacteriophage vB_SpsM-DS10 (Accession No. OM373557).
A composition comprising isolated bacteriophage vB_SpsM-DH2 and an isolated bacteriophage vB_SpsM-DS10.
A composition comprising an isolated bacteriophage with greater than 95%, 96%, 97%, 98%, 99%, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.6%, 99.7%, 99.8%, 99.9%, or 99.95% genomic sequence identity to the genomic sequences of vB_SpsM-DH2 (SEQ ID NO:
- 1), and/or vB_SpsM-DS10 (SEQ ID NO:
- 3).
A device, comprising, on, in, and/or around the device, isolated bacteriophages vB_SpsM-DH2, and/or vB_SpsM-DS10.
A method of obtaining lytic bacteriophages comprising,
- a) obtaining hair and/or skin sample(s) from one or more subjects,
- b) isolating phages from the sample(s), and
- c) analyzing the genome of isolated phages to predict lytic capacity and/or directly determining plaque forming capacity of the phages by exposing a target bacteria to the isolated phages.
Dependencies are inferred from the claim text.