Transdermal delivery device for peptide delivery and methods of use
AssigneesPassPort Technologies, Inc., National University Corporation Hokkaido University, National University Corporation Hamamatsu University School of Medicine
InventorsHirotoshi Adachi, Jeremiah Meloch, Melissa Lerman, Yuki Yamada, Toshiharu Suzuki, Haruka Yasuda, Yasuomi Ouchi
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Abstract
Disclosed herein are patches, methods, devices, and systems for delivering a non-aggregating peptide, such as alcadein and its fragments, into a subject. In some aspects, the patch includes a backing, a matrix comprising a non-aggregating peptides disposed within the matrix, and a release liner. In other aspects, the method includes opening at least one channel in the subject's skin, applying the patch described herein, thereby treating a disease or disorder associated with the brain, such as Alzheimer's disease.
Claims61
A patch for delivering a non-aggregating peptide into a subject, the patch comprising:
- a backing;
- a matrix comprising a non-aggregating peptide disposed within the matrix;
- and
- a release liner,
- wherein the release liner is configured to be removed before application to a subject's skin.
The device of 25 or 26, wherein the device has a poration energy from about 2 to about 6 mJ/filament, 4 mJ/filament, or 8 mJ/filament.
Dependencies are inferred from the claim text.