Highly elastic patches and masks for delivery of therapeutic agents

A method of manufacturing a therapeutic patch comprising the steps of:

• a) transfer coating the adhesive formula onto a release liner using a knife over roller system,
• b) moving the coated release liner through an oven until dry, where all solvents and water are evaporated and cross linking or fusing occurs to form an adhesive layer,
• c) laminating a 4 way stretch fabric onto the coated release liner to form a coated fabric using web guides that control fabric tension and movement along the transverse direction during the lamination process
• d) and optionally laminating an adhesive barrier layer to the 4 way stretch fabric prior to laminating the coated release liner to form a coated fabric,
• e) curing the coated fabric for 48-120 hours,
• f) kiss cut or die cutting coated fabric into the patch shapes,
• g) adding a perforation(s) or kiss cut(s) to the liner of the coated fabric,
• h) and optionally placing coated fabric on a corrugated core, and winding to create a roll.

A method of delivering a pain-relieving agent to a subject, said method apply a patch comprising:

• a) fabric layer made of synthetic fibers stretchable in both directions along a longitudinal axis and stretchable in both directions along a transverse axis
• b) an adhesive layer on said face side of the fabric layer, and
• c) a pain-relieving agent and penetration enhancing agent dispersed in said adhesive layer, to a skin surface of said subject;
• and maintaining said patch on said skin surface for a period of time sufficient for said pain relieving agent to be delivered to said subject.