Medical treatment system and methods using a plurality of fluid lines

A system for calculating a change in fluid volume in a pumping chamber of a pneumatically actuated diaphragm pump using a gas having a heat capacity ratio of n, the system comprising:

• a control chamber separated from the pumping chamber by a flexible diaphragm;
• a fluid inlet or outlet of the pumping chamber;
• a valve connecting the control chamber to a pressurized source of the gas;
• a pressure sensor fluidly connected to the control chamber;
• a controller that receives pressure data from the pressure sensor, that controls the valve, and that is configured to regulate pressure in the control chamber by opening or closing the valve;
• wherein the controller is configured to compute a change in volume of the control chamber as fluid enters or leaves the pumping chamber by monitoring a pressure change in the control chamber when the valve is closed;
• said computation assigning a first chamber volume to a first measured pressure, and calculating a second chamber volume based on a second later measured pressure using an equation in which a ratio of the second measured pressure to the first measured pressure is assumed to be equal to a ratio of the first chamber volume to the second chamber volume, raised to a power between 1 and n.

A method for determining an amount of fluid delivered by a diaphragm pump having a pumping chamber separated from a pneumatically actuated control chamber by a diaphragm, and having pneumatically actuated inlet and outlet valves, the method comprising having a controller:

• close the outlet valve, open the inlet valve, and connect the control chamber to a negative pressure source to apply negative pneumatic pressure to the diaphragm pump to draw fluid into the pumping chamber;
• close the inlet valve, connect the control chamber to the positive pressure source, isolate the control chamber, measure a first control chamber pressure, measure a first reference chamber pressure in a reference chamber having a known volume, connect the control chamber to the reference chamber, and calculate a first volume of the control chamber;
• open the outlet valve, and connect the control chamber to a positive pressure source to apply a positive pneumatic pressure to the diaphragm pump to expel fluid from the pumping chamber;
• close the outlet valve;
• vent the control chamber to reduce pressure in the control chamber toward atmospheric pressure;
• connect the control chamber to the positive pressure source, isolate the control chamber, measure a second control chamber pressure, measure a second reference chamber pressure, connect the control chamber to the reference chamber, and calculate a second volume of the control chamber;
• and
• determine the amount of fluid delivered by the diaphragm pump based on the first and second volumes of the control chamber.

A method for determining an amount of fluid delivered by a pumping cassette comprising a first and a second diaphragm pump each said diaphragm pump having a pumping chamber separated from a pneumatically actuated control chamber by a diaphragm, and each having pneumatically actuated inlet and outlet valves, the method comprising having a controller perform for each said diaphragm pump the steps of:

• closing the outlet valve, opening the inlet valve, and connecting the control chamber to a negative pressure source to apply negative pneumatic pressure to the diaphragm pump to draw fluid into the pumping chamber;
• closing the inlet valve, connecting the control chamber to the positive pressure source, isolating the control chamber, measuring a first control chamber pressure, measuring a first reference chamber pressure in a reference chamber having a known volume, connecting the control chamber to the reference chamber, and calculating a first volume of the control chamber;
• opening the outlet valve, and connecting the control chamber to a positive pressure source to apply a positive pneumatic pressure to the diaphragm pump to expel fluid from the pumping chamber;
• closing the outlet valve;
• venting the control chamber to reduce pressure in the control chamber toward atmospheric pressure;
• connecting the control chamber to the positive pressure source, isolating the contol chamber, measuring a second control chamber pressure, measuring a second reference chamber pressure, connecting the control chamber to the reference chamber, and calculating a second volume of the control chamber;
• and
• determining the amount of fluid delivered by the diaphragm pump based on the first and second volumes of the control chamber;
• wherein
• expelling fluid from the pumping chamber of the second diaphragm pump is performed after the control chamber of the first diaphragm pump is vented, and expelling fluid from the pumping chamber of the first diaphragm pump is performed after the control chamber of the second diaphragm pump is vented.

A system for measuring a volume of liquid in a pumping chamber of a peritoneal dialysis pump cassette comprising:

• a base unit in which the pump cassette can be installed, the base unit including a control block having a control chamber depression configured to mate with the pumping chamber of the pumping cassette, and to move a flexible diaphragm between the pumping chamber and the control chamber under positive or negative pneumatic pressure;
• the control chamber depression being in communication via one or more pump actuation valves in the base unit with a source of positive or negative pressure, and in communication via a vent valve in the base unit with a vent connected to atmospheric pressure;
• a controller configured to control the one or more pump actuation valves to operate the pumping cassette to fill the pumping chamber with liquid and to deliver liquid from the pumping chamber;
• the controller configured to control one or more pneumatically actuated membrane inlet and outlet valves in the pump cassette via one or more inlet and outlet actuation valves in the base unit connected to the source of positive or negative pneumatic pressure;
• the controller also configured to measure pneumatic pressure in the control chamber via a pressure sensor, and to calculate a volume of liquid in the pumping chamber, the calculation involving pneumatically pressurizing the control chamber before taking a pressure measurement;
• wherein the controller is configured to connect the control chamber with the vent after commanding a liquid delivery stroke of the pump cassette and before pneumatically pressurizing the control chamber to perform a pumping chamber liquid volume calculation.