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US 2025/0345293 A1Published application
Plasminogen Activator Inhibitor-1 (PAI-1) Inhibitor and Method of Use
AssigneesThe Regents of the University of Michigan, Eastern Michigan University
InventorsDaniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li
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Abstract
Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
Claims10
1-25. (canceled)
A compound having a structure which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.