Biotechnological production of desferrioxamines and analogs thereof
AssigneesEvonik Operations GmbH, Evonik Dr. Straetmans GmbH
InventorsSteffen SCHAFFER, Mirja WESSEL, Alexander THIEMANN, Hans Henning WENK
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Abstract
A recombinant microbial cell is capable of producing at least one compound having structural Formula II from a carbon source: In Formula II, n=2-3; R1=H or COCH3 or CH2CH2COX with X=OH or O—; R2=CH3 or CH2CH2COX with X=OH or O— where the cell comprises a genetic modification to increase activity relative to its wild-type cell of E4 where E4 is a desferrioxamine or bisucaberin synthetase (EC 6.3.-.-) (E4i) capable of converting N5-aminopentyl-N-(hydroxy)-succinamic acid to desferrioxamine B or H or at least one other linear desferrioxamine or bisucaberin according to Formula II.
Claims16
A recombinant microbial cell for producing at least one compound having structural Formula II from a carbon source:
- n=2-3
- R1=H or COCH3 or CH2CH2COX with X=OH or O—
- R2=CH3 or CH2CH2COX with X=OH or O— wherein the cell comprises a genetic modification to increase activity relative to its wild-type cell of E4 wherein:
- E4 is a desferrioxamine or bisucaberin synthetase (EC 6.3.-.-) (E41) capable of converting N5-aminopentyl-N-(hydroxy)-succinamic acid to desferrioxamine B or H or at least one other linear desferrioxamine or bisucaberin according to Formula II.
Dependencies are inferred from the claim text.