Antisense oligomers against monoamine oxidase b and use thereof
AssigneesInstitute for Basic Science, Korea Advanced Institute of Science and Technology
InventorsC. Justin LEE, Moonsun SA, Mridula Neeraj Kumar BHALLA, Jin Kuk KIM, Eunji JUNG, Minsung PARK
Life of this patent
Estimating the term…
Abstract
The present invention relates to antisense oligomers against monoamine oxidase B and uses thereof, and more particularly, to antisense oligomers that modulate the expression level of a gene encoding monoamine oxidase B, specifically the mRNA of the gene, or a protein encoded thereby, and uses thereof for preventing, alleviating or treating liver disease, obesity or neurological disease.
Claims16
An oligomer of 13 to 35 nt in length, which inhibits MAOB gene expression by hybridization with at least 13 contiguous nucleobases of a whole pre-mRNA sequence of MAOB set forth in SEQ ID NO:
- 41 through A:
- T or G:
- C Watson-Crick pairing or G:U, I:A, I:C, or I:U wobble pairing.
Dependencies are inferred from the claim text.