System and methods for monitoring autonomic nervous system function using multi-sensor signal analysis

A method for monitoring autonomic nervous system (ANS) function in a subject, the method comprising:

• a. acquiring a first physiological signal related to heart activity of the subject;
• b. acquiring one or more physiological signals using at least one sensor selected from the group consisting of:
• i. a blood pressure sensor;
• ii. a respiration sensor;
• iii. a sudomotor activity sensor;
• iv. a pulse wave sensor;
• v. an electroencephalography (EEG) sensor;
• vi. an electromyography (EMG) sensor;
• and
• vii. a motion sensor;
• c. receiving, processing and analyzing the physiological signals, by a processing unit to:
• i. monitor and/or detect, in real time, at least one of:
• 1. an autonomic nervous system dysfunction of the subject;
• and
• 2. a change in a physiological state of the subject;
• and
• ii. determine, based on the detection, an output condition;
• d. performing, based on the output condition, at least one of:
• i. generating an alert;
• ii. initiating a treatment;
• or
• iii. storing data.

A non-transitory computer-readable storage medium comprising instructions that, when executed by one or more processors, cause the one or more processers to:

• a. receive a first physiological signal related to heart activity of the subject;
• b. receive one or more physiological signals from at least one sensor selected from the group consisting of:
• i. a blood pressure sensor;
• ii. a respiration sensor;
• iii. a sudomotor activity sensor;
• iv. a pulse wave sensor;
• v. an electroencephalography (EEG) sensor;
• vi. an electromyography (EMG) sensor;
• and
• vii. a motion sensor;
• c. process and analyze the physiological signals to monitor and/or detect, in real time, at least one of:
• i. an autonomic nervous system dysfunction of the subject;
• and
• ii. a change in a physiological state of the subject;
• d. determine, based on the detection, an output condition;
• and
• e. perform, based on the output condition, at least one of:
• i. generating an alert;
• ii. initiating a treatment;
• or
• iii. storing data.