Therapeutic interfering particles for corona virus

An inhibitor of SARS-CoV-2 transcription regulating sequences (TRSs) that can bind to one or more of:

• TRS1-L:
• 5′-cuaaac-3′ (SEQ ID NO:36), TRS2-L:
• 5′-acgaac-3′ (SEQ ID NO:37), TRS3-L:
• 5′-cuaaacgaac-3′ (SEQ ID NO:38), or a combination thereof.

A pharmaceutical composition comprising a pharmaceutically acceptable excipient, (a) an inhibitor of SARS-CoV-2 transcription regulating sequences (TRSs) that can bind to one of more of:

• TRS1-L:
• 5′-cuaaac-3′ (SEQ ID NO:36), TRS2-L:
• 5′—acgaac-3′ (SEQ ID NO:37), TRS3-L, 5′-cuaaacgaac-3′ (SEQ ID NO:38), or a combination thereof;
• and (b) a recombinant SARS-CoV-2 construct, the construct comprising:
• at least 100 nucleotides of a SARS-CoV-2 5′ untranslated region (5′UTR), at least 100 nucleotides of a SARS-CoV-2 3′ untranslated region (3′UTR), or a combination thereof.