Compositions and methods for treating metabolic disease
AssigneeThe Regents of the University of California
InventorZhenqi Zhou
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Abstract
The present disclosure relates to compositions and methods for treating obesity-related diseases. In some aspects, methods are provided for increasing the expression and/or activity of Dj 1 protein in a subject in need thereof.
Claims24
A method of treating a metabolic disorder, reducing fat accumulation in the liver, or reducing blood glucose levels, comprising administering to a patient in need thereof a therapeutically effective amount of a Dj1 polypeptide or fragment thereof or a nucleic acid molecule encoding a Dj1 polypeptide or fragment thereof.
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A composition comprising:
- a Dj1 polypeptide or fragment thereof or a nucleic acid molecule encoding the Dj1 protein or fragment thereof;
- and
- a pharmaceutically acceptable carrier, wherein the Dj1 polypeptide or fragment thereof comprises an amino acid sequence at least 70% identical to SEQ ID NO:
- 1, 3, or 4;
- or
- wherein the nucleic acid molecule encoding the Dj1 polypeptide or fragment thereof comprises a nucleic acid sequence that is at least 70% identical to SEQ ID NO:
- 2 or 5.
A method of detecting, determining susceptibility to, or determining the progression of muscle injury in a subject, the method comprising determining a Dj1 polynucleotide or polypeptide level in a sample from the subject, wherein an elevated or increased Dj1 polynucleotide or polypeptide level in the subject relative to a reference or control is indicative of, indicates the subject is susceptible to, or indicates the progression of muscle injury.
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Dependencies are inferred from the claim text.