Deuterated secnidazole for use in the treatment of bacterial vaginosis and methods and uses thereof
AssigneeEvofem Biosciences, Inc.
InventorsRichard John Holl, Kurt Nielsen, James Garegnani
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Abstract
The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.
Claims21
1-20. (canceled)
A method for treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof in a subject in need thereof, comprising:
- administering to the subject a therapeutically effective amount of a compound of formula I, wherein the compound of formula I is:
- or a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, wherein X1 to X10 are independently selected from the group consisting of hydrogen and deuterium, and at least one of X1 to X10 is deuterium.
The method according to 10, wherein the compound of formula I does not affect the contraceptive efficacy of the additional compound.
Dependencies are inferred from the claim text.