Solid form of naphthylamine mitophagy inducer, and preparation method therefor, pharmaceutical composition thereof and use thereof
AssigneeHangzhou PhecdaMed Co., Ltd.
InventorsDong LIU, Ronghai WU, Zhen TIAN
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Abstract
The present application discloses solid form of naphthylamine-type mitochondrial autophagy inducer, and preparation method therefor, pharmaceutical composition and use thereof. Various solid forms of the compound of formula (I) are prepared and obtained in the present application, such as sodium salt, potassium salt, calcium salt, tromethamine salt, lysine salt, tert-butylammonium salt, diisopropylammonium salt, ethanolammonium salt, and diethanolammonium salt of the compound of formula (I).
Claims14
A solid form of a pharmaceutically usable salt of a compound of formula (I);
A solid form of a free acid of a compound of formula (I);
- wherein at least one characteristic peak of 2θ selected from 8.92° (±0.2°) and 23.31° (±0.2°) is showed in a X-ray powder diffraction pattern of the solid form of the free acid of the compound of formula (I);
A method for preparing a solid form of a sodium salt of a compound of formula (I), wherein the method comprises the steps of:
- dissolving the compound of formula (I) in a reaction medium, and adding a base containing sodium and reacting to obtain.
Dependencies are inferred from the claim text.