In vivo crosslinkable hydrogels with covalently attached dye for medical applications
AssigneeBoston Scientific Scimed, Inc.
InventorsLiming Crandall, Rick William Dorn, Joseph Thomas Delaney, JR.
Life of this patent
Estimating the term…
Abstract
In some aspects, the present disclosure pertains to systems that comprise (a) one or more reactive multi-arm polymers that comprises three or more polymer arms linked to a core region, each arm comprising a hydrophilic polymer segment and a first reactive moiety, (b) one or more reactive multifunctional compounds comprising a plurality of second reactive moieties that are reactive with the first reactive moieties, and (c) a covalently attached dye molecule. Other aspects the present disclosure pertain to methods of treatment using such systems and dye-containing hydrogel compositions comprising crosslinked reaction products of such systems.
Claims20
A system comprising (a) one or more reactive multi-arm polymers that comprises three or more polymer arms linked to a core region, each arm comprising a hydrophilic polymer segment and a first reactive moiety, (b) one or more reactive multifunctional compounds comprising a plurality of second reactive moieties that are reactive with the first reactive moieties, and (c) a covalently attached dye molecule.
A method of treatment comprising administering to a subject a mixture that comprises (a) one or more reactive multi-arm polymers that comprises three or more polymer arms linked to a core region, each arm comprising a hydrophilic polymer segment and a first reactive moiety, (b) one or more reactive multifunctional compounds comprising a plurality of second reactive moieties that are reactive with the first reactive moieties, and (c) a covalently attached dye molecule under conditions such that the one or more reactive multi-arm polymers and the one or more reactive multifunctional compounds covalently crosslink after administration to form a hydrogel, wherein the covalently attached dye molecule is covalently attached to the hydrogel.
A dye-containing hydrogel composition comprising a crosslinked reaction product of (a) one or more reactive multi-arm polymers that comprises three or more polymer arms linked to a core region, each arm comprising a hydrophilic polymer segment and a first reactive moiety, (b) one or more reactive multifunctional compounds comprising a plurality of second reactive moieties that are reactive with the first reactive moieties, and (c) a covalently attached dye molecule, wherein the covalently attached dye molecule is covalently attached to the crosslinked reaction product.
Dependencies are inferred from the claim text.