Modified plant virus system for delivery of nucleic acids into mammalian cells
OwnerJames Dahlman, Curtis Dobrowolski +1inventors
InventorsJames Dahlman, Curtis Dobrowolski, Kalina Paunovska
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Abstract
The disclosure provides modified plant viruses designed for delivering a nucleotide of interest into mammalian cells. The modified plant viruses include a plant virus nucleotide sequence (e.g. fragment) that is capable of transfecting a mammalian cell when that mammalian cell expresses a receptor for the modified plant virus. Accordingly, the disclosure also provides receptors for the modified plant viruses as well as methods of using the receptor or the modified plant virus and receptor.
Claims17
A modified plant virus comprising a plant virus nucleotide sequence and a nucleotide sequence capable of exhibiting a therapeutic effect in a mammalian cell, wherein the virus is capable of transfecting a mammalian cell, wherein the mammalian cell is modified to express a receptor for the modified plant virus.
-71. (canceled)
Dependencies are inferred from the claim text.