Novel vaccines for tuberculosis

Abstract

Embodiments of the present disclosure pertains to a genetically altered bacterial strain that lacks functional versions of at least three of the following proteins: FbpA; SapM; Zmp1; DosR; FadD26; SigH; nuoG; and Eis. In some embodiments, the bacterial strain lacks functional versions of at least the following proteins: FbpA; SapM; Zmp1; and DosR. In some embodiments, the bacterial strain lacks functional versions of at least the following proteins: FbpA; SapM; Zmp1; DosR; FadD26; and SigH. In some embodiments, the bacterial strain lacks functional versions of at least the following proteins: SapM; Zmp1; and nuoG. Further embodiments of the present disclosure pertain to methods of treating or preventing a bacterial infection in a subject by administering to the subject a bacterial strain of the present disclosure. In some embodiments, the bacterial infection is tuberculosis.

Dependencies are inferred from the claim text.