Chimeric antigen receptor, cell expressing said receptor, pharmaceutical composition including said cell, method for producing said cell, and polynucleotide or vector including nucleotide sequence encoding said chimeric antigen receptor

A chimeric antigen receptor includes a target antigen binding region, a transmembrane region, and a signal transduction region, wherein the transmembrane region includes at its C-terminus a first polypeptide selected from the group consisting of (1a) to (1c) below.

• (1a) a polypeptide consisting of an amino acid sequence in which at least 3 amino acids from the C-terminus are deleted in the amino acid sequence set forth in SEQ ID NO:
• 1;
• (1b) a polypeptide consisting of an amino acid sequence having 85% or more sequence identity to the amino acid sequence of the polypeptide of (1a);
• and
• (1c) a polypeptide consisting of an amino acid sequence in which one or more amino acids are mutated in the amino acid sequence of the polypeptide of (1a).