Mitofusin activators having an endocyclic-bonded carbonyl group and methods for use thereof

Abstract

Compositions capable of promoting mitofusin activation may include a mitofusin activator having a structure represented by any stereoisomer thereof, or any pharmaceutically acceptable salt thereof. G is N or CH, and A is an optionally substituted 5- or 6-membered cycloalkyl or heterocycloalkyl ring. X is (CH2)3, OCH2CH2, CH2OCH2, CH2CH2O, Cyc, CH2Cyc, NR1(CH2)3, NR1OCH2CH2, NR1CH2OCH2, NR1CH2CH2O, or NR1Y, R1 is H or C1-C6 alkyl, and Cyc is 1,2-cyclopropyl, 1,2-cyclobutyl, 1,3-cyclobutyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 1,2-cyclohexyl, 1,3-cyclohexyl, or 1,4-cyclohexyl. Z is (CH2)n or (CH2)n1O(CH2)n2. R2 is an optionally substituted aryl or heteroaryl group. Variable n is an integer ranging from 1 to 5, variable n1 is an integer ranging from 0 to 4, variable n2 is an integer ranging from 0 to 4, and n1+n2=n−1.

Dependencies are inferred from the claim text.