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US 2025/0332113 A1Published application
Adhesive particles for active delivery
AssigneeThe Trustees of the University of Pennsylvania
InventorsDaeyeon LEE, Minjun OH, Jaehyun KIM, Li-Wei CHANG, Robert Leon MAUCK, George R. DODGE, Hyun KOO
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Abstract
Provided are adhesive dendritic particles, which particles can be used for sustained delivery of an active agent to a location or locations at which the particles are adhered. Also provided are related methods of use and methods of formulating the disclosed particles.
Claims35
An adhesive composition, comprising:
- an adhesive dendritic particle that comprises (1) a polymeric phase with dendrites extending therefrom, and (2) at least one active ingredient, and
- (a) the adhesive dendritic particle having an aqueous phase disposed within the polymeric phase and at least one active ingredient present within the aqueous phase,
- (b) the adhesive dendritic particle having at least one active ingredient present in the polymeric phase, or
- (c) both (a) and (b), and
- the adhesive dendritic particle being configured to adhere to a location of a subject so as to allow for release of at least one active ingredient to the location.
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A method, comprising:
- forming an emulsion comprising an adhesive dendritic particle that comprises (1) a polymeric phase with dendrites extending therefrom, and (2) at least one active ingredient, and
- (a) the adhesive dendritic particle having an aqueous phase disposed within the polymeric phase and at least one active ingredient being present within the aqueous phase, or
- (b) the adhesive dendritic particle having at least one active ingredient being present in the polymeric phase, or
- (c) both (a) and (b),
- optionally wherein forming the emulsion comprises one or more of sonication, homogenization, stirring, or using droplet-forming flow channels.
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Dependencies are inferred from the claim text.