Enzyme immobilized adhesive layer for analyte sensors
AssigneeDexCom, Inc.
InventorsTed Tang Lee, Shanger Wang, Jiong Zou
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Abstract
Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
Claims18
A device for measurement of a concentration of an analyte, the device comprising:
- a sensor configured to generate a signal associated with the concentration of the analyte in interstitial fluid;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising:
- a first layer comprising a first-layer polymer, wherein the first-layer polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units, and wherein at least one of the zwitterionic repeating units is an internal zwitterionic repeating unit in a backbone of the first-layer polymer and the at least one of the zwitterionic repeating units comprise at least one moiety selected from the group consisting of a carboxyl betaine, a sulfo betaine, a phosphor betaine, and derivatives thereof.
Dependencies are inferred from the claim text.