Method for cardiac repair
AssigneeThe Regents of the University of California
InventorsSylvia Evans, Paola Cattaneo, Nuno Guimarães-Camboa
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Abstract
This disclosure provides methods to modulate cardiac regeneration in a mammalian cardiac cell or progenitor, comprising contacting the mammalian cardiac cell with a DOT1L gene modulator.
Claims20
A method to modulate cardiogenesis in a mammalian cardiac cell or mammalian cardiac progenitor cell, comprising contacting the cell with a DOT1L gene modulator.
A method of promoting cardiac regeneration or de novo cell cycle of a post-mitotic mammalian cardiac cell, comprising contacting the cardiac cell with an agent that inhibits expression of an endogenous DOT1L gene or function in the cell, thereby promoting cardiac regeneration in the cell or de novo cell cycle of a post-mitotic cardiac cell.
A method of promoting cardiac regeneration or treating cardiac injury or disease in a subject in need thereof, comprising administering to the subject an agent that inhibits expression of an endogenous DOT1L gene in a mammalian cardiac cell in the subject, thereby promoting cardiac regeneration or treating cardiac injury or disease in the subject.
Dependencies are inferred from the claim text.