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AssigneeAgilent Technologies LDA UK Limited
InventorsPavel Matousek, Julia Griffen, Andrew Owen, Lee Dowden, Marco Pinto
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Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light, and a spectral distortion of the collected light arising during scattering through the sample is determined. A property of the sample is then quantified using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion.
A method of Raman spectral analysis of a sample, comprising:
The method of any preceding claim wherein the delivery region and the collection region are spaced apart by between 2 mm and 20 mm.
The method of any preceding claim wherein quantifying the property of the sample comprises applying the target Raman spectral features to a quantification model which then provides the property of the sample.
The method of any preceding claim further comprising measuring each of a plurality of reference spectral features in the collected light, wherein the spectral distortion of the collected light is determined using the plurality of reference spectral features.
The method of any preceding claim wherein determining the spectral distortion comprises applying the plurality of measured reference spectral features to a distortion model which then provides the spectral distortion.
The method of any preceding claim wherein the sample is a diffusely scattering solid object, and optionally wherein the sample has a diffuse scattering transport length of less than 1 mm.
The method of any preceding claim wherein the sample is a pharmaceutical dosage form.
The method of any preceding claim wherein the probe light delivered to the delivery region is near infrared laser light, and wherein the spectral distortion arises from at least one of wavelength dependent infrared absorption, and wavelength dependent diffuse scattering, during scattering of the probe light through the sample.
Apparatus for Raman spectral analysis of a sample, comprising:
Dependencies are inferred from the claim text.