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US 2025/0320293 A1Published application
Anti-trem2 single-domain antibody and use thereof
AssigneeRegenecore Biotech Co., Ltd
InventorsZhipeng SU, Yang WANG, Wei XIE
Life of this patent
Estimating the term…
Abstract
Provided is an anti-TREM2 single-domain antibody, consisting of heavy chains including CDR1 represented by any one of SEQ ID NOs: 34-40, CDR2 represented by any one of SEQ ID NOs: 41-45, and CDR3 represented by any one of SEQ ID NOs: 46-50. The single-domain antibody has good affinity with TREM2.
Claims21
1-12. (canceled)
An anti-TREM2 single-domain antibody, comprising a heavy chain comprising a heavy chain CDR1 as set forth in any one of SEQ ID NO:
- 34 to SEQ ID NO:
- 40 or a heavy chain CDR1 having one to five conserved amino acid substitution with respect to any one of SEQ ID NO:
- 34 to SEQ ID NO:
- 40, a heavy chain CDR2 as set forth in any one of SEQ ID NO:
- 41 to SEQ ID NO:
- 45 or a heavy chain CDR2 having one to five conserved amino acid substitution with respect to any one of SEQ ID NO:
- 41 to SEQ ID NO:
- 45, and a heavy chain CDR3 as set forth in any one of SEQ ID NO:
- 46 to SEQ ID NO:
- 50 or a heavy chain CDR2 having one to five conserved amino acid substitution with respect to any one of SEQ ID NO:
- 46 to SEQ ID NO:
- 50.
9 more elements
Dependencies are inferred from the claim text.