Compositions and Methods for Cancer Immunotherapy
AssigneesIN8bio, Inc., The UAB Research Foundation
InventorsWilliam HO, Lawrence S. LAMB, JR.
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Abstract
The present invention provides compositions and methods for combination therapy comprising administering to a patient in need thereof, drug-resistant immunotherapy, immune checkpoint inhibitors, and chemotherapy for the treatment of cancer.
Claims21
A method for the treatment of cancer in a patient in need thereof comprising the steps of:
- i. obtaining a population of isolated cytotoxic immune cells comprising γδ T-cells, natural killer (NK) cells, or any combination thereof, wherein the population of cytotoxic immune cells have been genetically modified to be resistant to one or more therapeutic agents;
- ii. administering to the patient an effective amount of one or more of the therapeutic agents to which the genetically modified cytotoxic immune cells of step (i) are resistant;
- iii. administering to the patient the population of genetically modified cytotoxic immune cells of step (i);
- and
- iv. administering to the patient an effective amount of at least one immune checkpoint inhibitor.
A composition comprising at least one checkpoint inhibitor, and an isolated population of cytotoxic immune cells comprising γδ T-cells, NK cells, or any combination thereof, wherein greater than about 50% of the population of cytotoxic immune cells express a polypeptide that confers resistance to a chemotherapy agent.
Dependencies are inferred from the claim text.