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US 2025/0313675 A1Published application
Facile Assembly of Soft Nanoarchitectures and Co-Loading of Hydrophilic and Hydrophobic Molecules via Flash Nanoprecipitation
AssigneeNorthwestern University
InventorsEvan A. Scott, Sean D. Allen
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Abstract
Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
Claims26
A method for preparing nanocarriers by flash precipitation comprising the steps of:
- (i) providing an organic phase solution comprising an amphiphilic copolymer and a process solvent, wherein the amphiphilic copolymer has a glass transition temperature below 0° C.,
- (ii) providing an aqueous phase solution comprising an aqueous solvent,
- (iii) mixing the organic phase solution and the aqueous phase solution to form a mixture, and
- (iv) introducing the mixture into a reservoir to cause precipitation of the amphiphilic copolymer as a nanocarrier.
1 more element
A method for preparing nanocarriers by flash precipitation comprising the steps of:
- (i) providing an organic phase solution comprising an amphiphilic copolymer and a process solvent, wherein the amphiphilic copolymer has a glass transition temperature below 0° C.,
- (ii) providing an aqueous phase solution comprising an aqueous solvent and an target molecule,
- (iii) mixing the organic phase solution and the aqueous phase solution to form a mixture, and
- (iv) introducing the mixture into a reservoir to cause precipitation of the amphiphilic copolymer as a nanocarrier loaded with the target molecule.
1 more element
A method for preparing nanocarriers by flash precipitation comprising the steps of:
- (i) providing an organic phase solution comprising an amphiphilic copolymer and a process solvent, wherein the amphiphilic copolymer has a glass transition temperature below 0° C.,
- (ii) providing an aqueous phase solution comprising an aqueous solvent and an target molecule,
- (iii) mixing the organic phase solution and the first aqueous phase solution to form a mixture,
- (iii) portioning the mixture into a first portion and a second portion,
- (iv) mixing the first portion and the second portion to form a second mixture, and
- (v) introducing the second mixture into a reservoir to cause precipitation of the amphiphilic copolymer as a nanocarrier loaded with the target molecule.
3 more elements
Dependencies are inferred from the claim text.