Bacillus subtilis strains producing new mycosubtilin isoforms
OwnerFrançois Coutte, Arnaud Delecroix +4inventors
InventorsFrançois Coutte, Arnaud Delecroix, Debarun Dhali, Philippe Jacques, Tambi Kar, Yazen Yaseen
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Abstract
The present disclosure relates to the field of molecules of antifungal biosurfactants of bacterial origin. More particularly, the present disclosure relates to new Bacillus Subtilis strains producing new isoforms of mycosubtilins, a preparation method therefor, and compositions containing same. These novel mycosubtilin isoforms exhibit improved antifungal activities and reduced cytotoxic properties compared with mycosubtilins of the prior art.
Claims12
A genetically modified Bacillus sp strain, which is the Bacillus subtilis strain deposited on Jul. 30, 2020, under number CNCM I-5565 at the Collection nationale de cultures de micro-organismes (CNCM) of the Institut Pasteur (Paris, France).
A mycosubtilin isoform selected from the group consisting of Gln1-C16 and Gln1-C17 isoforms.
A method of killing or inhibiting a Z. tritici strain, the method comprising:
- contacting the Z. tritici strain with at least one mycosubtilin selected from the group consisting of Gln1-C16 and Gln1-C17 isoforms and the Gln3-C16 isoform.
Dependencies are inferred from the claim text.