2-methyl-2-thiazoline salt
AssigneeMyrodia Therapeutics Co., Ltd.
InventorsKiyoshi TANIGAWA, Kazuo MARUHASHI
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Abstract
A solid derivative of 2-methyl-2-thiazoline which is easy to handle during formulation and is useful as an active pharmaceutical ingredient for pharmaceutical products is provided. A 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, or a deuterated form thereof, a pharmaceutical composition containing the same, a prophylactic or therapeutic agent for hypoxic injury, ischemia-reperfusion injury or inflammation, which contains the same, and a method for producing a 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, or a deuterated form thereof.
Claims29
A 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, or a deuterated form thereof.
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A method for producing a 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, comprising
- mixing 2-methyl-2-thiazoline, 1,5-naphthalenedisulfonic acid or saccharin, and a solvent, and
- isolating the obtained solid of the 1,5-naphthalenedisulfonic acid salt or saccharin salt of 2-methyl-2-thiazoline.
A method for producing a deuterated form of a 1,5-naphthalenedisulfonic acid salt or a saccharin salt of 2-methyl-2-thiazoline, wherein the method is selected from the following (A), (B), and (C):
- (A) a method for producing a deuterated form of a saccharin salt of 2-methyl-2-thiazoline, comprising
- mixing a saccharin salt of 2-methyl-2-thiazoline and deuterated methanol, and
- isolating the obtained deuterated form of the saccharin salt of 2-methyl-2-thiazoline;
- (B) a method for producing a deuterated form represented by the formula (1)
- or the formula (2)
- comprising mixing 2-methyl-d3-2-thiazoline and a deuterated form of 1,5-naphthalenedisulfonic acid in a solvent to obtain a deuterated form represented by the formula (1) or the formula (2), and
- (C) a method for producing a deuterated form represented by the formula (3)
- comprising mixing a saccharin salt of 2-methyl-2-thiazoline and deuterated methanol to obtain a deuterated form represented by the formula (3).
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Dependencies are inferred from the claim text.