Preparation and Application of Deuterated 4-Phenyl-4-Piperidinols
AssigneeNanchang Double Angel Biotechnology Development Co., Ltd.
InventorsZhenghong CAO, Meimei FAN, Jiumei WU
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Abstract
The invention relates to the preparation and application of deuterated 4-phenyl-4-piperidinols, the general structural formula of which is represented by formula (I) or formula (II). The present invention also discloses the preparation and application of these compounds, and pharmaceutically acceptable salts and pharmaceutical compositions containing thereof. The compounds of the present invention can be used for the treatment of pain.
Claims20
Deuterated 4-phenyl-4-piperidinols characterized in that the structural general formula of the compound is represented by formula (I):
- wherein R1 is selected from one of a hydrogen, a C1-C3 alkyl, a fully deuterated or partially deuterated C1-C3 alkyl;
- R2 is a phenyl or a 2,4,5-trifluorophenyl;
- R3 and R4 are respectively selected from one of a methyl(CH3) and a deuterated methyl(CD3), both of which are not simultaneously a methyl;
- X is
Deuterated 4-phenyl-4-piperidinols characterized in that the structural general formula of the compound is represented by formula (II):
- wherein R1 is selected from one of a hydrogen, a C1-C3 alkyl, a fully deuterated or partially deuterated C1-C3 alkyl;
- R2 is a phenyl or a 2,4,5-trifluorophenyl;
- R3 and R4 are respectively selected from one of a methyl(CH3) and a deuterated methyl(CD3), which are not simultaneously a methyl;
- X is
Dependencies are inferred from the claim text.