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US 2025/0304528 A1Published application
Oligo-benzamide analogs and their use in cancer treatment
AssigneeBoard of Regents, The University of Texas System
InventorsGanesh RAJ, Jung-Mo AHN, Ratna K. VADLAMUDI
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Abstract
The present disclosure compounds of the formulae: wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer.
Claims26
A compound of the formula:
- wherein:
- R6 is halo, —NO2, alkyl(C≤12), substituted alkyl(C≤12), amido(C≤12), substituted amido(C≤12), or —NHC(O)CH(R6a)NH2, wherein:
- R6a is aralkyl(C≤18), substituted aralkyl(C≤18), or the side chain of a canonical amino acid;
- R7 and R8 are each independently alkyl(C≤12), -alkanediyl(C≤12)-cycloalkyl(C≤12), aralkyl(C≤18), or a substituted version of any of these groups;
- and
- R9 is cycloalkyl(C≤12), aryl(C≤12), aralkyl(C≤18), heteroaryl(C≤12), heteroaralkyl(C≤18), or a substituted version of any of these groups;
- or
- a group of the formula:
- wherein:
- L2 is —CO2— or —C(O)NRL2—, wherein:
- RL2 hydrogen, alkyl(C≤12), or substituted alkyl(C≤12);
- R9a is aryl(C≤12), aralkyl(C≤18), heteroaryl(C≤12), heteroaralkyl(C≤18), or a substituted version of any of these groups;
- or a pharmaceutically acceptable salt thereof.
10 more elements
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-103. (canceled)
Dependencies are inferred from the claim text.